Similar cellular heterogeneity for other GPCRs does trigger cell-specific responses to inflammatory cues in vascular and inflammatory cells47,48, but our current understanding of GPCR heterogeneity in the endometrium is rudimentary, and whether LHCGR-positive cells are relevant in pathological conditions such as infertility, miscarriage and endometriosis awaits elucidation. This evidence concerns the gene LHCGR and spontaneous abortion.