ADAM15 and malignant colon neoplasm: However, in some cancers, such as colon cancer, the expression of ADAM15 inhibits cancer metastasis and is associated with poor prognosis in patients with colon cancer [30]; In our study, we found that ADAM15 was an independent prognostic factor and that the high expression of ADAM15 correlated with the overall survival (OS) of lung cancer patients.