However, in some cancers, such as colon cancer, the expression of ADAM15 inhibits cancer metastasis and is associated with poor prognosis in patients with colon cancer [30]; In our study, we found that ADAM15 was an independent prognostic factor and that the high expression of ADAM15 correlated with the overall survival (OS) of lung cancer patients. Here, ADAM15 is linked to colonic neoplasm.