Our recent study has identified that CD151 regulate EGFR signalling pathway by affecting integrin α3β1 in NSCLC, based on the research on CD151 and its-related genes [14], we found that ADAM15 was significantly correlated with CD151, which aroused our strong interest in exploring the relationship between ADAM15 and CD151. This evidence concerns the gene ADAM15 and non-small cell lung carcinoma.