ADAM15 and non-small cell lung carcinoma: Then, we performed co-immunoprecipitation to show that ADAM15 can interact with α3/α6 (Fig. 8D), furthermore, we found CD151 interference in NSCLC indeed decreased the combination of ADAM15 and integrin α3/α6, but the combination of ADAM15 and integrin αV was not reduced (Fig. 8E), the results proved ADAM15 regulate integrin α3/α6 by cooperating with CD151, but regulate integrin αV is not affected by CD151.