ACLY and metastatic malignant neoplasm: First, we chose ten genes that encode key enzymes in lipid anabolic and catabolic metabolism associated with metastatic cancer [5, 12, 13]: ACLY, ACACA, FASN, SCD, LPIN1, DGAT1, MGLL, PLA2G2A, PLD1, and CPT1A. Then, we applied the analysis for expression, overall survival (OS), and disease-free survival (DFS) via the online web server GEPIA2 (Fig. 1A).