Further research showed that the compound prescription of MC3 and lipidosis (DSPC, cholesterol, DMG-PEG2000, and DSPE-PEG2000) was applied for the delivery of IL-10 mRNA as an inflammatory bowel disease therapeutic, which expressed the anti-inflammatory cytokine IL-10 in Ly6c+ inflammatory leukocytes and alleviated symptoms in a dextran sodium sulfate colitis model.147 Correcting the genetic variance of cystic fibrosis transmembrane conductance regulator (CFTR) is an efficacy target to cure cystic fibrosis. Here, IL10 is linked to colitis.