Fabry disease can be improved by using nanoparticles sustainably to deliver α-galactosidase A mRNA into a mouse and nonhuman primate.439 Mutation of the SERPINA1 gene leads to alpha 1-antitrypsin (AAT) deficiency and damages the liver where the AAT protein is produced. The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.