Comparative analysis of the expression of the DYRK1A-SRSF6-TNNT2 pathway in myocardial tissue from individuals with and without Down syndrome revealed increased levels of phosphorylated SRSF6 and ~ 50% higher expression of fetal TNNT2 transcript variants in trisomic myocardium [16]. This evidence concerns the gene DYRK1A and Down syndrome.