Circulating markers of neutrophil extracellular traps (NETs), such as nucleosomal citrullinated histone H3 (H3Cit-DNA), cell-free DNA (cfDNA), and neutrophil elastase (NE), are increased in COVID-19 patients and NETs are known to contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome [26–28]. Here, ELANE is linked to COVID-19.