SLC1A2 and Parkinson disease: In addition, deficits in glutamate transporters have been consistently reported upon acute neurotoxin injection in rodents [9, 10, 101] as well as in genetic models of PD [11, 28, 37], and selective ablation of nigral and striatal astrocytic Glt-1 expression induces a parkinsonian-like phenotype in mice [66, 102].