These results can be attributed to doxorubicin-associated cardiotoxicity [3], doxorubicin, and paclitaxel associated upregulation of pro-inflammatory cytokines including TNF-α [43, 44], doxorubicin-induced oxidative stress [23, 45], and paclitaxel-induced peripheral neuropathy secondary to activation of inflammatory cascade [4, 11]. Here, TNF is linked to peripheral neuropathy.