Regarding platelet activation makers, PCSK9 levels were significantly and positively associated with sP-selectin and sCD40L in the whole cohort (r = 0.158, P = 0.015; r = 0.176, P < 0.001; respectively), and the correlations were stronger in DM patients (r = 0.181, P = 0.001; r = 0.279, P < 0.001; respectively) than in non-DM patients (r = 0.141, P = 0.065; r = 0.086, P = 0.001; respectively). This evidence concerns the gene PCSK9 and diabetes mellitus.