PCSK9 and heart failure: As presented in Table 5, univariate Cox regression analysis revealed a significant association between high PCSK9 levels and increased risk of MACEs or rehospitalization for heart failure in the whole cohort (HR: 1.420, 95% CI 1.033–1.953, P = 0.031; HR: 2.463, 95% CI 1.011–5.988, P = 0.047; respectively).