MACEs major adverse cardiac events (including all-cause death, recurrent myocardial infarction, ischemic stroke and rehospitalization for heart failure), PCSK9 proprotein convertase subtilisin/kexin type 9, CAD coronary artery disease, LVEF left ventricular ejection fraction, TIMI thrombolysis in myocardial infarction, AHA American Heart Association, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, HbA1C hemoglobin A1c, eGFR estimated glomerular filtration rate, hs-CRP high-sensitivity C reactive protein. Here, PCSK9 is linked to heart failure.