In DM patients receiving ticagrelor, PCSK9 levels were significantly and positively associated with MPA and MAADP at 7 days post-PCI (r = 0.236, P = 0.041; r = 0.336, P = 0.013; respectively), whereas no correlations were found in non-DM patients receiving ticagrelor. Here, PCSK9 is linked to diabetes mellitus.