Our group described, for the first time, subtype-specific lncRNA signatures for six major cytogenetic subgroups of pediatric AML, namely, Down syndrome (DS) and non-DS acute megakaryoblastic leukemia (AMKL), inv[16], t[8;21], and AML with KMT2A rearrangement (t[9;11] and t[10;11]) [3]. The gene discussed is KMT2A; the disease is acute myeloid leukemia.