CDKN2B-AS1 and acute myeloid leukemia: LncRNA ANRIL, which is upregulated in both AML and ALL, acts as an oncogenic lncRNA by epigenetic silencing of its antisense tumor suppressor gene p15 [14, 50] As for other oncogenic lncRNAs, recent studies indicate a correlation of ANRIL expression to poor survival in patients with AML [51].