Indeed, a recent meta-analysis hinted at a differing effect of obesity on outcomes based on cancer subtype: Lohmann and colleagues observed a larger magnitude of the deleterious effect of excess body weight in triple-negative and hormone receptor-positive, HER2-negative breast cancer as compared to hormone receptor-positive, HER2-positive breast cancer39. This evidence concerns the gene NR4A1 and obesity due to melanocortin 4 receptor deficiency.