We compared 32 models that included protein expression levels for BCAM, SIGLEC-14, and ANGPTL-3 as well as critical risk factors for BPD development, i.e., GA, sex, birth weight, and eoi, which are the most important risk factors associated with BPD development,14 to determine the model with the highest sensitivity and specificity (highest AUC) for the separation of moderate and severe BPD cases from no BPD while explaining the data only by the most important variables (lowest AIC). This evidence concerns the gene ANGPTL3 and bronchopulmonary dysplasia.