In human RyR2, nearly 300 pathogenic mutations have been reported as arrhythmogenic heart diseases, including catecholaminergic polymorphic ventricular tachycardia (CPVT)5–8, and idiopathic ventricular fibrillation (IVF)9–12. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.