Our results support the findings of Lourenço et al. and suggest that GDF-15 predicts a range of CV events such as MI/stroke and SCD (OR = 1.736, (1.265–2.380), p = 0.0345; supplementary Table 3) in the setting of hospitalized HF with CAD history. This evidence concerns the gene GDF15 and Schnyder corneal dystrophy.