CDK2 and lentivirus infection: To further elucidate that CDK2 is a critical target of HHT in leukemia treatment, the THP1 CDK2-wt and THP1 CDK2-3As/T160E cells were stably expressed with luciferase by lentivirus infection and inoculated into NSG mice by tail vein injection, and these mice were treated with HHT or vehicle control as described above.