The experiment demonstrated that CDK2 knockout led to a significant reduction in leukemia cell proliferation and prolongation of survival of THP1 xenograft mice; meanwhile, HHT treatment also inhibited the leukemia development in THP1 xenograft mice but barely had effect on THP1 CDK2−/− xenograft mice (Fig S7B, C). This evidence concerns the gene CDK2 and leukemia.