Previous studies have showed that GLUD1 contributes to leucine sensing in the regulating of autophagy, affecting cell proliferation, metastasis, metabolism, and drug resistance in various cancers [22, 25, 34, 35], in which leucine acts as a potent suppressor of autophagy by activating MTORC1 that is an essential negative regulator of autophagy [36–40]. The gene discussed is GLUD1; the disease is cancer.