Based on our RNA-seq data analysis, EphA2 and VEGFA were enriched in growth and vasculature development in HCT116 cells (Fig. 2H); therefore, we evaluated the tumor‐promoting ability of METTL3 and its target genes, EphA2 and VEGFA, by upregulating EphA2 and VEGFA using a GV230 overexpression vector. The gene discussed is EPHA2; the disease is neoplasm.