In conclusion, these data suggest that METTL3 regulates EphA2 and VEGFA via different IGF2BP-dependent mechanisms to promote VM formation via PI3K/AKT/mTOR and ERK1/2 signaling, which upregulates the expression of the VM‐related gene, vimentin, in CRC tumorigenesis. Here, EPHA2 is linked to colorectal carcinoma.