Compared with expression in the normal colonic epithelial cell line, NCM460, METTL3 levels were also significantly upregulated in six CRC cell lines (HT29, LoVo, DLD-1, SW480, SW620, and HCT116) at both at mRNA and protein levels, consistent with the results from CRC tissues (Fig. 1G, H). This evidence concerns the gene METTL3 and colorectal carcinoma.