The results showed that four writers (METTL3, METTL16, RBM15, and VIRMA) and six readers (YTHDF1, YTHDF2, HNRNPA2B1, HNRNPC, and IGF2BP2/3) were significantly upregulated in CRC tumors compared to adjacent normal tissues. The gene discussed is YTHDF2; the disease is colorectal carcinoma.