TP63 and EEC syndrome: Heterozygous pathogenic variants in TP63 cause multiple syndromes, including EEC syndrome, AEC syndrome (OMIM #106260), RHS (OMIM #129400), acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome (OMIM #103285), and split hand/foot malformation (OMIM #605289), depending on the combinations of ectodermal dysplasia, limb malformation, and cleft lip/palate symptoms2.