For example, Kindlin-2 is known to play a critical role in regulation of cell-extracellular matrix adhesion, integrin signaling and metabolic reprogramming [36–47, 51, 55, 60–62, 67], which likely contribute to Kindlin-2 deficiency-induced inhibitory effects on breast cancer growth and metastasis described in the current study. This evidence concerns the gene FERMT2 and breast carcinoma.