To test the role of Kindlin-2 in breast cancer metastasis directly, we employed an experimental metastasis mouse model in which Kindlin-2 was knocked down from BT549 cells by short hairpin RNA (shRNA)-based RNA interference (Fig. 6E) and then equal number of Kindlin-2 knockdown BT549 cells and the control BT549 cells, respectively, were injected into the mouse tail vein. The gene discussed is FERMT2; the disease is breast carcinoma.