Reactivation of the Hh pathway and upregulation of GLI1 expression have been observed in conditions with fibrocyte-induced tissue fibrosis [17], such as idiopathic pulmonary fibrosis [44], biliary fibrosis [45], renal fibrosis [46], and cardiac fibrosis [47]. The gene discussed is GLI1; the disease is idiopathic pulmonary fibrosis.