BRCA1 and ovarian carcinoma: For example, the three BRCA founder mutations [BRCA1 185delAG (c.68_69del), 5382insC (c.5266dup), and BRCA2 6174delT (c.5946del)] have high carrier frequency (2.17%) in Ashkenazi Jewish population contributing to high risk of breast and ovarian cancer (Gabai-Kapara et al, 2014).