BRCA1 and cancer: This is represented by the high cancer-risk deleterious variants in BRCA1 and BRCA2 that the carrier rate reaches to one in a few hundreds of individuals in general population, for example, one in 384 in Japanese population (Momozawa et al, 2018), one in 265 in Chinese Han and Mexican populations (Fernández-Lopez et al, 2019; Dong et al, 2021), one in 256 in Malaysian population (Wen et al, 2018), one in 189 in US population (Manickam et al, 2018), and the highest of one in 46 in Ashkenazi Jewish population (Gabai-Kapara et al, 2014).