For example, Fanconi Anemia caused by 12 mutated DDR genes of FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, RAD51C, SLX4, XRCC2, and ERCC4 are all autosomal recessive, whereas breast cancer caused by eight DDR genes of BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD51D, and RAD54L are all autosomal dominant. The gene discussed is CHEK2; the disease is breast carcinoma.