Other TIM-3 ligands include the phospholipid PtdSer expressed on apoptotic cells, the alarmin high mobility group box 1 (HMGB1) that binds to DNA released from dying cells and the glycolipid CEA cell adhesion molecule 1 (CEACAM1) known to be highly expressed on tumour cells [115]. The gene discussed is HAVCR2; the disease is neoplasm.