ERBB2 and cancer: c-MYC (MYC), epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), AKT serine/threonine kinase 1 (AKT), K-Ras GTPase (KRAS), serine/threonine-protein kinase B-Raf (BRAF), and MEK1 protein kinase (MEK) are classic examples of powerful oncogenes that activate several distinct tumorigenic axes in cancers (3, 4, 5).