STAT1 and COVID-19: 2020; Wang 2020; Lokhande et al. 2021). Through the construction of a molecular docking model between hub host genes and hub compounds, it was found that folic acid and proteins ILB, PTGS2, and STAT1 were stable binding, and oestrogen stably bound to IL6 and IL8. Oestrone has good binding properties to proteins, and exogenous oestrogen is recommended as a drug for COVID-19 prevention and treatment (Zsuzsanna 2020).