The action of the H19 gene and its products in tumor onset and hyperplastic lesions is evident, with the antagonism of H19 lncRNA and p53 and the activity of one of its gene products, miR-675, in promoting cellular and chromosomal instability being well described, as well as its hyperexpression in the presence of external factors such as hypoxia [37]. The gene discussed is TP53; the disease is neoplasm.