Similar to the case of SGBS cells, aromatase expression and E2 production were significantly increased in the Ifi204f/f preadipocytes when cultured with CM obtained from cocultured plates of isolated mouse bone marrow-derived macrophages (BMDM) and E0771 cells, which are mouse ER-positive mammary tumor cells [31]. Here, CYP19A1 is linked to breast cancer.