However, there were many individually rare mutations, which together revealed emergent network patterns between MGSs and either CS, or ARVC, or DCM: cadherins, laminins, integrins, metalloproteases, nitric oxide synthases, ryanodine receptors, adenylate cyclases, subunits of protein kinase A etc. They contributed to the NEA scores with multiple network links so that for example the median edge counts between genes of MGSs and of the pathways were 22...45 in MB and 497...890 in LUAD. This evidence concerns the gene ADCY1 and Cowden syndrome 1.