Although the role of CS in cancer was rarely considered central, cell migration and adhesion do involve modulation of cell motility and shape where ion channels and pumps play major roles, so that CS genes are known for both downregulation and functional implication in cancers (Tajada and Villalobos, 2020; Phan et al., 2017; Litan and Langhans, 2015). The gene discussed is CS; the disease is cancer.