GST pull-down assay showed that though RCC2 interacted with CORO1C∆CE, the membrane co-localization of RCC2 with CORO1C∆CE disappeared (Figure 2F), while further PAK4 knockdown also ceased both the interaction of RCC2 with CORO1C (Figure 2G) and the leading edge co-localization of RCC2 in gastric cancer cells (Figure 2H). Here, RCC2 is linked to gastric cancer.