Analysis of tumor immune infiltration showed the elevated expression levels of IGF2BP3, DPCR1, HOXD10, TRIM7, and ZIC5 tended to be correlated with the increased tumor infiltrating B cells, CD8+ T cells, CD4+ T cells, and APCs including macrophages and DCs in COAD patients (Figure S4). This evidence concerns the gene ZIC5 and neoplasm.