EDN1 and Hypertension: In addition, increased concentrations of ET‐1 contributes to endothelial dysfunction, hypertension, (Cardillo et al., 2000; Weil et al., 2011; Williams et al., 2002), a decline in cardiopulmonary function, and an overall increased risk of CVD; particularly in obese individuals (Serés et al., 2003).