Pyroptosis plays critical roles in LPS‐induced sepsis, including via canonical and noncanonical pathways, toll‐like receptor 4 (TLR4)‐dependent and TLR4‐independent pathways,54, 55 Gasdermin D (GSDMD) and beyond‐GSDMD‐mediated pathways.56 Here, GSDMD is linked to Sepsis.