To study whether PANX1–IL‐33 signalling plays a role in the defence against sepsis caused by GNB infection,9 we analyzed the PANX1–IL‐33 axis in a cohort comprising 13 patients with sepsis caused by GNB and 26 patients with no infection; this cohort is independent of those examined in our previous studies9, 37 (Figure 1A). This evidence concerns the gene PANX1 and infection.