Recently, an increasing number of studies has provided promising results on the effect of NURR1 activation and gene delivery in vitro and in vivo in PD models, which are able to protect mDA neurons from neurotoxicity and motor behaviors associated with DA neurotransmission (De Miranda et al., 2015; Hammond et al., 2015; Oh et al., 2015). The gene discussed is NR4A2; the disease is Parkinson disease.