As the temporal and frontal cortices display pathological overgrowth in autistic infants, toddlers, and young children (Carper & Courchesne, 2005; Eyler et al., 2012; Hazlett et al., 2011), and the temporal cortex has been frequently used for the transcriptome analysis in autism (Garbett et al., 2008; Voineagu et al., 2011), the temporal cortex tissues of autistic mice (offspring of VPA‐treated mice) were collected, in which downregulation of TGIF2 was detected. This evidence concerns the gene TGIF2 and autism.