RAB5A and cancer: Unlike the group treated with milk-exosome/cis-FITC, in the group A2780CP cells treated with simple cis-FITC, cis-FITC were detected co-localized with Rab5 and LysoTracker, suggesting that cis-FITC trafficked to and trapped in endosomes as well as lysosomes (Figure 8A), resulting in the restriction of the anti-cancer efficacy, consistent with previous observations that the vitality of A2780CP cells treated with simple cis-FITC is better than treated with simple milk-exosome/cis-FITC (Figure 3A).