Further work will be required to delineate the detailed mechanism of GPR30-regulated beige adipogenesis, body weight control, as well as the possible interaction between GPR30 and ERα-mediated metabolic actions, which could potentially lead to a novel therapeutic strategy to efficiently prevent the development of obesity and obesity related metabolic diseases in females. The gene discussed is GPER1; the disease is obesity due to melanocortin 4 receptor deficiency.