We analyzed the expression of prognostic S100s in paracancerous tissues, tumor marginal tissues, and tumor core tissues and found that the expression levels of S100A2-4, S100A8, S100A10-11, and S100A16 were significantly increased from paracancerous tissue, tumor marginal tissues to tumor core tissues (Figure 10(a)). This evidence concerns the gene S100A16 and neoplasm.