S100A16 and glioblastoma: Compared with LGG, the expression levels of S100A2-4, S100A6, S100A8-13, S100A16, S100B, S100P, and S100Z were distinctly upregulated in GBM; meanwhile, the expression levels of S100A1 and S100A18 (HRNR) were significantly downregulated in GBM (Figures 2(a) and 2(c)).