The promoter regions of ATXN2 and ATXN3 are methylated in SCA2 and SCA3 patients with expanded repeats (Laffita-Mesa et al., 2012; Wang et al., 2017), and increased levels of methylation are found in the CTCF binding domains of ATXN7 in SCA7 patients (Libby et al., 2008). This evidence concerns the gene ATXN3 and spinocerebellar ataxia 7.