Moreover, a number of lncRNAs and TFs that may regulate MAPK-type AD have been identified in our study, some of which have well-defined roles in AD, such as GAS5, which may promote the recovery of neurons and cholinergic nervous system (Zhao et al., 2019), MALAT1 has a neuroprotective effect (Li et al., 2020), and PPARA regulates autophagy to clear Aβ (Luo et al., 2020). Here, MALAT1 is linked to Alzheimer disease.