MAPK8 and Alzheimer disease: The Sankey diagram obtained for autophagic-type AD indicated that the lncRNAs HOTAIR, MALAT1, and SNHG16 and the TF HSF2 may target pathway genes such as MAPK8 and TBK1 to affect key pathways such as autophagy, mitophagy, NOD-like receptor signaling, and Toll-like receptor signaling (Figure 7A).