For example, activation of Akt may play a therapeutic role in neurodegenerative disease (D’Antoni et al., 2017; Matsuda et al., 2018), while the abnormal, sustained activation of neuronal PI3-K/Akt/mTOR signaling is an early feature of AD (Griffin et al., 2005; O’ Neill, 2013). This evidence concerns the gene AKT1 and Alzheimer disease.