In addition to Aβ toxicity (O’Brien and Wong, 2011), several processes have been related to the pathogenesis of AD, including hyperphosphorylation of tau protein (Martin et al., 2011), gene mutation, central cholinergic neuron damage, microglia cell activation (Paolicelli et al., 2017), free radical damage, and oxidative stress (Chen and Zhong, 2014). Here, MAPT is linked to Alzheimer disease.