Recent evidence suggested that the overexpression of SNHG12 specifically combined miR-129-5p in the glioblastoma, causing the upregulation of MAPK1 and E2F7, which impaired temozolomide (TMZ)-induced apoptosis and the G1/S cell cycle conversion, resulting in the appearance of acquired TMZ resistance (29). This evidence concerns the gene MAPK1 and glioblastoma.