TUBB2B and FGF12 have been suggested to play vital functions in prostate cancer (Liotti et al., 2021), neuroblastoma (Zafar et al., 2021), and esophageal squamous cell carcinoma (Bhushan et al., 2017); however, their roles in HBV-related GC development have never been documented and merit further investigations. This evidence concerns the gene FGF12 and Familial prostate cancer.