TUBB2B and FGF12 have been suggested to play vital functions in prostate cancer (Liotti et al., 2021), neuroblastoma (Zafar et al., 2021), and esophageal squamous cell carcinoma (Bhushan et al., 2017); however, their roles in HBV-related GC development have never been documented and merit further investigations. Here, TUBB2B is linked to esophageal squamous cell carcinoma.