The susceptible-specific hub genes encoding for the Dickkopf Like Acrosomal Protein 1 (Dkkl1) and the neurogenic differentiation transcription factor 2 (NeuroD2), increased susceptibility to social stress, and induced behavioral despair and anxiety-like behaviors when overexpressed in the ventral hippocampus (vHPC) but not in the mPFC of male mice (Bagot et al., 2016). The gene discussed is DKKL1; the disease is Anxiety.