The analyses revealed that this lncRNA was consistently downregulated across brain regions in women but not men with MDD, and its expression was strongly correlated with protein coding genes previously associated with MDD including DUSP6, ARC, NR4A1, EGR1, and EGR2 (Orsetti et al., 2008; Covington et al., 2010; Li et al., 2015; Labonté et al., 2017). Here, ARC is linked to major depressive disorder.