Of these, 16,181 patients (26%) and 2366 patients (4%) had initiated first-line PBC and first-line ICI plus PBC, respectively, on or before January 31, 2020, and 165 (1%) and 59 patients (2%), respectively, also had evidence of a positive BRAF mutation (Supplementary Table 1). Here, BRAF is linked to primary biliary cholangitis.