Recent studies have also revealed that the CH1 domain of CBP/p300 and the C-TAD of the HIF-1α complex is preferentially required for the expression of a multitude of hypoxic genes (GLUT-1, LDH-A, MCT-4, and VEGF) involved in cancer progression and adaptation to the hypoxic tumor microenvironment [24, 31, 36–38]. This evidence concerns the gene HIF1A and cancer.