As for the clinical feature analysis of core genes, it offered the positive results that the mRNA expressions of ACTN1, CAV1, COL1A2, COL6A3, FN1, RHOA, VWF, HLA-DPA1, and HLA-B in kidney tubules negatively correlated with GFR, and the mRNA expression of ACTN1, COL1A2, PRKCB, ITGB2, HLA-DPA1, and HLA-B in kidney tubules positively correlated with proteinuria; the mRNA expressions of COL1A1, HLA-F, and ITGB2 in kidney tubules positively correlated with SCR; the HLA-F mRNA expressions level positively correlated with ACR in DN patients. The gene discussed is HLA-B; the disease is liver dysplastic nodule.