Notably, the mRNA expression levels of ACTN1, CAV1, COL1A2, COL6A3, FN1, RHOA, VWF, HLA-DPA1, and HLA-B in kidney tubules were negatively relevant to the GFR in DN patients (Figure 9(a)), indicating that these core genes may promote the development of DN. This evidence concerns the gene COL6A3 and liver dysplastic nodule.