In the present study, after clinical cross and index validation from GSE99325, GSE104954, and the Nephroseq v5 platform, the expression of ACTN1, CAV1, PDGFRA, COL1A2, COL6A3, RHOA, VWF, FN1, HLA-DPB1, ITGB2, HLA-DRA, HLA-DPA1, and HLA-DMB were significantly upregulated in DN patients in at least one dataset, GSE99325 or GSE104954. This evidence concerns the gene HLA-DPB1 and liver dysplastic nodule.