Notably, the mRNA expression levels of ACTN1, CAV1, COL1A2, COL6A3, FN1, RHOA, VWF, HLA-DPA1, and HLA-B in kidney tubules were negatively relevant to the GFR in DN patients (Figure 9(a)), indicating that these core genes may promote the development of DN. Here, RHOA is linked to liver dysplastic nodule.