Notably, the mRNA expression levels of ACTN1, CAV1, COL1A2, COL6A3, FN1, RHOA, VWF, HLA-DPA1, and HLA-B in kidney tubules were negatively relevant to the GFR in DN patients (Figure 9(a)), indicating that these core genes may promote the development of DN. The gene discussed is HLA-B; the disease is liver dysplastic nodule.