CAV1 [33], Caveolin-1, acts as a scaffolding protein within caveolar membranes [34] and is crucial to promote profibrotic signal transduction resulted from several known stimuli in DN, such as the most prominent factors hyperglycemia and angiotensin II, thus representing a novel and hopeful therapeutic option for DN [33]. Here, CAV1 is linked to liver dysplastic nodule.