MAPT and early-onset autosomal dominant Alzheimer disease: Furthermore, MRI-pathological studies failed to correlate the rate of hippocampal atrophy with early hippocampal tau NFT during ageing.29 In turn, the exceptional vulnerability of hippocampal CA1 pyramidal neurons to Alzheimer’s disease neuropathological changes30 may explain differential atrophy between the hippocampus and the entorhinal cortex over time.