Furthermore, our MRI scheme of atrophy progression includes structures characterizing three of the four distinct trajectories of tau deposition, namely amygdala, hippocampus and entorhinal cortex (limbic trajectory), middle temporal gyrus, parahippocampal cortex and other temporal areas (lateral temporal trajectory) and parietal (angular gyrus) cortices (medial temporal lobe-sparing trajectory). Here, MAPT is linked to Atrophy.