SLC1A2 and dementia: The miR-107c and miR-29a could target glutamate transporter-1 (GLT-1) to modulate excitotoxicity in the CNS; miR-107c could target GLT-1 directly to evaluate the glutamate accumulation and neuronal excitotoxicity, whereas miR-29a mainly acts on p53 upregulated modulator of apoptosis (PUMA), which could attenuate OS and protect neurons from dementia caused by ischemic injury (50).