Studies showed that different from A20−/−mice, mice bearing a point mutation in either the OTU domain (A20OTU/OTUmice) or ZnF4 domain (A20ZnF4/ZnF4) do not develop severe inflammatory phenotype (Lu et al., 2013; Wertz et al., 2015), however, the A20ZnF7/ZnF7 mice can spontaneously develop arthritis and other autoimmune diseases. The gene discussed is ZNF711; the disease is arthritic joint disease.