Since GATA2 can induce the transcription of murine double minute 2 (MDM2) to suppress the p53 signaling pathway, serum-derived exosomal miR-15a can promote apoptosis and cell cycle arrests of osteosarcoma cells via GATA2/MDM2/p53 axis, as demonstrated in Figure 4 (Wu et al., 2021). This evidence concerns the gene TP53 and osteosarcoma.