Meanwhile, overexpression of Vps4A in hepatocellular carcinoma (HCC) cells induced the selection of exosomal miR-193a-3p, miR-320a, miR-132-3p, miR-27b-3p and miR-92a-3p, probably through PI3K/Akt axis (Wei et al., 2015). This evidence concerns the gene AKT1 and hepatocellular carcinoma.