Exosomal miR-1468-5p derived by tumor-derived exosomes directly targeted homeobox containing 1 (HMBOX1) in human dermal lymphatic endothelial cell (HDLEC) and inhibited suppressor of cytokine signaling 1 (SOCS1) expression to activate the JAK2/STAT3 pathway and mediate HDLEC reprogramming to repress CD8+ T cell immunity (Zhou et al., 2021). This evidence concerns the gene HMBOX1 and neoplasm.