In intrahepatic cholangiocarcinoma, exosomal miR-206 reduced the expression of LIM and SH3 protein 1 (LASP1) and suppressed the activity of STAT3 signaling to inhibit cholangiocarcinoma stem-like characteristics and TGF-β1 secretion. The gene discussed is LASP1; the disease is intrahepatic cholangiocarcinoma.