In addition, a study of single nucleotide polymorphism (SNP) in 246 patients with RA was followed up for 6 years and it was found that the 695T > C (Ile232Thr) polymorphism in exon five of FcγRIIb gene could attenuate the signal of inhibitory receptor and aggravate the condition of RA and joint destruction (Li et al., 2003; Radstake et al., 2006). This evidence concerns the gene FCGR2B and rheumatoid arthritis.