Alternatively, carriers of the CC homozygote of POMC rs2071345 may not need to rely on lower level of alcohol dependence or be as sensitive to lower level of alcohol dependence as those with T allele of POMC rs2071345, suggesting higher level of alcohol dependence may not confer the same level of risk among carriers of the CC homozygote of POMC rs2071345. This evidence concerns the gene POMC and alcohol dependence.